[14C]Ethylenethiourea: Distribution, excretion, and metabolism in pregnant rats
| Autor: | J A Ruddick, D T Williams, K S Khera, W L Hierlihy |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Embryology
medicine.medical_specialty Erythrocytes Time Factors Health Toxicology and Mutagenesis Urine Maternal blood Toxicology Excretion Plasma Fetus Internal medicine medicine Animals Distribution (pharmacology) Ethylenethiourea Chemistry Imidazoles Thiourea Metabolism Rats Endocrinology Liver Sephadex Female Developmental Biology |
| Zdroj: | Teratology. 13:35-39 |
| ISSN: | 1096-9926 0040-3709 |
| DOI: | 10.1002/tera.1420130107 |
| Popis: | Following administration of single oral doses of [14C]ethylenethiourea (ETU) to pregnant rats maternal blood maintained peak radioactivity for 2 h, and the radioactivity was dispersed uniformly between the red blood cells and plasma. The level of radioactivity was distributed equally among several maternal tissues but was present in lower amounts in embryos. Twenty-four hours after treatment all tissues examined, except blood, were relatively clear of radioactivity and 72.8% of the total radioactivity given had been excreted in the urine. Elution patterns of metabolites from Sephadex separation suggested that ethylenethiourea was degraded very little. The teratological mechanism is discussed. |
| Databáze: | OpenAIRE |
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