| Autor: |
M. Dettori, N. Riccardi, D. Canetti, R.M. Antonello, A.F. Piana, A. Palmieri, P. Castiglia, A.A. Azara, M.D. Masia, A. Porcu, G.C. Ginesu, M.L. Cossu, M. Conti, P. Pirina, A. Fois, I. Maida, G. Madeddu, S. Babudieri, L. Saderi, G. Sotgiu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Pulmonology. |
| ISSN: |
2531-0437 |
| Popis: |
Lung transplantation can improve the survival of patients with severe chronic pulmonary disorders. However, the short- and long-term risk of infections can increase morbidity and mortality rates. A non-systematic review was performed to provide the most updated information on pathogen, host, and environment-related factors associated with the occurrence of bacterial, fungal, and viral infections as well as the most appropriate therapeutic options. Bacterial infections account for about 50% of all infectious diseases in lung transplanted patients, while viruses represent the second cause of infection accounting for one third of all infections. Almost 10% of patients develop invasive fungal infections during the first year after lung transplant. Pre-transplantation comorbidities, disruption of physical barriers during the surgery, and exposure to nosocomial pathogens during the hospital stay are directly associated with the occurrence of life-threatening infections. Empiric antimicrobial treatment after the assessment of individual risk factors, local epidemiology of drug-resistant pathogens and possible drug-drug interactions can improve the clinical outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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