A novel auto‐positioning method in Iodine‐125 seed brachytherapy driven by preoperative planning

Autor: Guobin Zhang, Zhiyong Yang, Xiaodong Ma, Shude Chai, Shan Jiang
Rok vydání: 2019
Předmět:
Male
Computer science
medicine.medical_treatment
Brachytherapy
auto‐positioning
Computed tomography
Radiotherapy Setup Errors
030218 nuclear medicine & medical imaging
Iodine Radioisotopes
Rats
Sprague-Dawley

03 medical and health sciences
0302 clinical medicine
Histogram
Preoperative Care
mental disorders
medicine
Animals
Radiation Oncology Physics
Dosimetry
Tissue Distribution
Radiology
Nuclear Medicine and imaging

Radiation treatment planning
Instrumentation
Radiation
Preoperative planning
medicine.diagnostic_test
Radiotherapy Planning
Computer-Assisted

Radiotherapy Dosage
iodine‐125 seed brachytherapy
Iodine 125 seed
Rats
Absolute deviation
preoperative planning
030220 oncology & carcinogenesis
Radiotherapy
Intensity-Modulated

treatment planning system
Monte Carlo Method
Algorithms
Software
Biomedical engineering
Zdroj: Journal of Applied Clinical Medical Physics
ISSN: 1526-9914
DOI: 10.1002/acm2.12591
Popis: Iodine‐125 seed brachytherapy has great potential in the treatment of malignant tumors. However, the success of this treatment is highly dependent on the ability to accurately position the coplanar template. The aim of this study was to develop an auto‐positioning system for the template with a design focus on efficiency and accuracy. In this study, an auto‐positioning system was presented, which was composed of a treatment planning system (TPS) and a robot‐assisted system. The TPS was developed as a control system for the robot‐assisted system. Then, the robot‐assisted system was driven by the output of the TPS to position the template. Contrast experiments for error validation were carried out in a computed tomography environment to compare with the traditional positioning method (TPM). Animal experiments on Sprague–Dawley rats were also carried out to evaluate the auto‐positioning system. The error validation experiments and animal experiments with this auto‐positioning system were successfully carried out with improved efficiency and accuracy. The error validation experiments achieved a positioning error of 1.04 ± 0.19 mm and a positioning time of 23.15 ± 2.52 min, demonstrating a great improvement compared with the TPM (2.55 ± 0.21 mm and 40.35 ± 2.99 min, respectively). The animal experiments demonstrated that the mean deviation of the seed position was 0.75 mm. The dose‐volume histogram of the preoperative planning showed the same as the postoperative dosimetry validation. A novel auto‐positioning system driven by preoperative planning was established, which exhibited higher efficiency and accuracy compared with the TPM.
Databáze: OpenAIRE
načítá se...