Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors
| Autor: | Nadezhda V. Loginova, Marina P. Sutunkova, Boris A. Katsnelson, Oleg H. Makeyev, Larisa A. Vlasova, Marina S. Vasilyeva, Roman V. Kozin, Ludmila G. Tulakina, Yakov B. Beikin, Larisa I. Privalova, Vladimir B. Gurvich, Irene E. Valamina, Artem V. Korotkov, Svetlana V. Pichugova, Anastasia E. Tyurnina, Vladimir Ya. Shur, Ilzira A. Minigalieva, Ekaterina P. Kireyeva, Eugene A. Shuman, Ekaterina V. Shishkina |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
CELL NUCLEUS
LIVER nanosilver nanogold bronchoalveolar lavage subchronic toxicity genotoxicity bioprotectors GLUTAMATE SODIUM GENOTOXICITY TOXICOKINETICS Pharmacology NANOGOLD medicine.disease_cause ANIMAL EXPERIMENT Silver nanoparticle PECTIN Oral administration LUNG ALVEOLUS MACROPHAGE Spectroscopy Chemistry NANOSILVER DRUG CYTOTOXICITY General Medicine GLYCINE HISTOPATHOLOGY TRANSMISSION ELECTRON MICROSCOPY Computer Science Applications FEMALE Biochemistry Toxicity CELL SUSPENSION BIOPROTECTORS NEUTROPHIL NANOTOXICOLOGY ENDOCYTOSIS SELENIUM chemistry.chemical_element PROTECTIVE AGENT AMINO ACID Calcium SPLEEN Article Catalysis BRONCHOALVEOLAR LAVAGE CALCIUM PHAGOCYTOSIS Inorganic Chemistry ACETYLCYSTEINE KIDNEY In vivo ANIMAL TISSUE medicine Toxicokinetics NONHUMAN Physical and Theoretical Chemistry ARTICLE Molecular Biology FISH OIL GOLD NANOPARTICLE SILVER NANOPARTICLE Organic Chemistry ATOMIC FORCE MICROSCOPY DNA FRAGMENTATION CONTROLLED STUDY MULTIVITAMIN ANIMAL CELL Nanotoxicology INTERNALIZATION RAT SUBCHRONIC TOXICITY MITOCHONDRION Genotoxicity CELLULAR DISTRIBUTION |
| Zdroj: | International Journal of Molecular Sciences; Volume 14; Issue 2; Pages: 2449-2483 International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms14022449 |
| Popis: | Stable suspensions of nanogold (NG) and nanosilver (NS) with mean particle diameter 50 and 49 nm, respectively, were prepared by laser ablation of metals in water. To assess rat's pulmonary phagocytosis response to a single intratracheal instillation of these suspensions, we used optical, transmission electron, and semi-contact atomic force microscopy. NG and NS were also repeatedly injected intraperitoneally into rats at a dose of 10 mg/kg (0.5 mg per mL of deionized water) three times a week, up to 20 injections. A group of rats was thus injected with NS after oral administration of a "bioprotective complex" (BPC) comprised of pectin, multivitamins, some amino acids, calcium, selenium, and omega-3 PUFA. After the termination of the injections, many functional and biochemical indices and histopathological features of the spleen, kidneys and liver were evaluated for signs of toxicity, and accumulation of NG or NS in these organs was measured. From the same rats, we obtained cell suspensions of different tissues for performing the RAPD test. It was demonstrated that, although both nanometals were adversely bioactive in all respects considered in this study, NS was more noxious as compared with NG, and that the BPC tested by us attenuated both the toxicity and genotoxicity of NS. © 2013 by the authors; licensee MDPI, Basel, Switzerland. |
| Databáze: | OpenAIRE |
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