Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells
| Autor: | Isabel Carrascoso, José M. Izquierdo, Carmen Sánchez-Jiménez |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Intracellular Fluid
Transcriptional Activation TIA1 DNA repair T-Lymphocytes T cell RNA-binding protein Poly(A)-Binding Proteins Biochemistry HeLa Antigen medicine Humans Molecular Biology biology Gene Expression Profiling RNA-Binding Proteins Cell Biology biology.organism_classification Molecular biology T-Cell Intracellular Antigen-1 Cell biology Gene expression profiling medicine.anatomical_structure Intracellular Genome-Wide Association Study HeLa Cells |
| Zdroj: | Biochemical Journal. 461:43-50 |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bj20140227 |
| Popis: | TIA (T-cell intracellular antigens)-knockdown HeLa cells show an increase in ribosomes and translational machinery components. This increase correlates with specific changes in translationally up-regulated mRNAs involved in cell-cycle progression and DNA repair, as shown in polysomal profiling analysis. Our data support the hypothesis that a concerted activation of both global and selective translational rates leads to the transition to a more proliferative status in TIA-knockdown HeLa cells. |
| Databáze: | OpenAIRE |
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