Pickering nano-emulsion as a nanocarrier for pH-triggered drug release
| Autor: | Sidy Mouhamed Dieng, Thierry F. Vandamme, Mounibé Diarra, Papa Mady Sy, Nicolas Anton, Saïd Ennahar, Nadia Messaddeq, Ysia Idoux-Gillet |
|---|---|
| Přispěvatelé: | Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Conception et application de molécules bioactives (CAMB), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg Inserm Faculté de médecine, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2018 |
| Předmět: |
Drug Compounding
Sonication Administration Oral Pharmaceutical Science Ibuprofen 02 engineering and technology 010402 general chemistry 01 natural sciences Drug Stability medicine Nanotechnology Technology Pharmaceutical [CHIM]Chemical Sciences Cyclooxygenase Inhibitors Solubility Active ingredient Drug Carriers Chemistry technology industry and agriculture Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology 3. Good health 0104 chemical sciences Bioavailability Drug Liberation Kinetics Delayed-Action Preparations Emulsion Nanoparticles Emulsions Nanocarriers Magnesium Oxide 0210 nano-technology Drug carrier Hydrophobic and Hydrophilic Interactions medicine.drug Nuclear chemistry |
| Zdroj: | International Journal of Pharmaceutics International Journal of Pharmaceutics, Elsevier, 2018, 549 (1-2), pp.299-305. ⟨10.1016/j.ijpharm.2018.07.066⟩ |
| ISSN: | 0378-5173 |
| Popis: | International audience; This study investigates the formulation of surfactant-free Pickering nano-emulsions able to release a drug at specific pH, in order to enhance its oral bioavailability. The stabilizing nanoparticles composed of magnesium hydroxide, were obtained by nano-precipitation method. The oil-in-water Pickering nano-emulsions stabilized with Mg(OH)2 nanoparticles, and encapsulating a model of hydrophobic drug (ibuprofen) were formulated following a high-energy process, using a sonication probe. The experimental approach explored the impact of all formulation parameters, composition and size of Mg(OH)2 nanoparticles, on the physico-chemical properties of the Pickering nano-emulsions. The system was characterized by DLS and transmission electron microscopy. In addition, Mg(OH)2 has the advantage of being solubilized in an acid medium leading to the destabilization of the nano-emulsion and the release of the active ingredient orally. The acid release study (pH = 1.2) showed cumulative release as a function of initial nanodroplet loading and saturation concentration. In basic media (pH = 6.8), we found a significant release of ibuprofen from the nano-emulsions that already had saturation in an acid medium. These nano-emulsions can not only protect patients from the side effects of acid medicines through the basic properties of hydroxides but also can contribute to the increase of the bioavailability of these drugs. In addition, once in the stomach pH is increased by hydroxides and promotes the release of active ingredients such as ibuprofen whose solubility is strongly influenced by pH. |
| Databáze: | OpenAIRE |
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