Effect of Pueraria mirifica on vaginal health
| Autor: | Urusa Theppisai, Jittima Manonai, Apichart Chittacharoen, Hathai Theppisai |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Pueraria Vaginal Diseases Placebo Vaginal disease Double-Blind Method Humans Medicine Adverse effect Gynecology Mucous Membrane Dose-Response Relationship Drug biology Plant Extracts business.industry Obstetrics and Gynecology Middle Aged medicine.disease biology.organism_classification Postmenopause Vasomotor System Menopause Treatment Outcome medicine.anatomical_structure Vagina Women's Health Female Vaginal atrophy business Phytotherapy Pueraria mirifica |
| Zdroj: | Menopause. 14:919-924 |
| ISSN: | 1072-3714 |
| DOI: | 10.1097/gme.0b013e3180399486 |
| Popis: | Objective: To evaluate the effect of Pueraria mirifica on vaginal symptoms, vaginal health index, vaginal pH,and vaginal cytology in healthy postmenopausal women.Design: A randomized, double-blind, placebo-controlled study. Healthy postmenopausal women, age 45 to 60years old, were enrolled voluntarily and randomly received 20, 30, or 50 mg of Pueraria mirifica in capsules orplacebo in identical capsules once daily for 24 weeks.Results: After 24 weeks of treatment, 71 women were evaluated. Fifty-one of 71 randomly received one of thethree doses of Pueraria mirifica, and the remaining 20 received placebo. The mean vaginal dryness symptom inthe Pueraria mirifica group decreased after 12 weeks of treatment. Pueraria mirifica increased vaginalmaturation index (parabasal:intermediate:superficial cells) from 46:43:11 to 11:65:24 after 24 weeks of treatment.There was no significant difference of adverse effects between the Pueraria mirifica and placebo groups in thisstudy.Conclusions: Pueraria mirifica was proven to exhibit estrogenicity on vaginal tissue, to alleviate vaginaldryness symptoms and dyspareunia, to improve signs of vaginal atrophy, and to restore the atrophic vaginalepithelium in healthy postmenopausal women.Key Words: Pueraria mirifica Y Vaginal symptoms Y Vaginal health index Y Vaginal cytology Y Menopause. |
| Databáze: | OpenAIRE |
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