Gut-associated lymphoid tissue or so-called 'dome' carcinoma of the colon: Review
| Autor: | Runjan Chetty, Aoife J McCarthy |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Colorectal cancer Gut-associated lymphoid tissue Lymphoglandular complex 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Dome-type carcinoma Eosinophilia business.industry Gastroenterology Germinal center Histology medicine.disease Desmoplasia Gastrointestinal-associated lymphoid tissue carcinoma Lymphatic system medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Systematic Review medicine.symptom business |
| Zdroj: | World Journal of Gastrointestinal Oncology |
| ISSN: | 1948-5204 |
| Popis: | Aim To present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon. Methods The English language medical literature on gut- or gastrointestinal-associated lymphoid tissue (GALT) or "dome" carcinoma of the colon was searched and appraised. Results GALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque- or "dome"-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence. Conclusion Increased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases. |
| Databáze: | OpenAIRE |
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