Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum
| Autor: | Veit Hornung, Rolf Müller, Frank Surup, Dhruv Chauhan, Marc Stadler, Jutta Niggemann, Eva Bartok, Matthias Keck, Jennifer Herrmann, Wiebke Zander |
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| Rok vydání: | 2018 |
| Předmět: |
Boron Compounds
0301 basic medicine Antifungal Agents Inflammasomes Antineoplastic Agents Gram-Positive Bacteria 01 natural sciences Biochemistry Small Molecule Libraries Mice 03 medical and health sciences Adjuvants Immunologic Cell Line Tumor NLR Family Pyrin Domain-Containing 3 Protein Boron containing medicine Animals Humans Secretion Myxococcales 010405 organic chemistry Chemistry Natural compound Fungi Stereoisomerism Inflammasome General Medicine Hyalangium minutum Anti-Bacterial Agents 0104 chemical sciences 030104 developmental biology Molecular Medicine Macrolides medicine.drug |
| Zdroj: | ACS Chemical Biology. 13:2981-2988 |
| ISSN: | 1554-8937 1554-8929 |
| Popis: | A Natural Compound Library containing myxobacterial secondary metabolites was screened in murine macrophages for novel activators of IL-1β maturation and secretion. The most potent of three hits in total was a so far undescribed metabolite, which was identified from the myxobacterium Hyalangium minutum strain Hym3. While the planar structure of 1 was elucidated by high resolution mass spectrometry and NMR data yielding an asymmetric boron containing a macrodiolide core structure, its relative stereochemistry of all 20 stereocenters of the 42-membered ring was assigned by rotating frame Overhause effect spectroscopy correlations |
| Databáze: | OpenAIRE |
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