Total Th1/Th2 cytokines profile from peripheral blood lymphocytes in normal pregnancy and preeclampsia syndrome
| Autor: | Iara dos Santos Fagundes, Raquel Jaqueline Eder Ribeiro, Carlos Eduardo Poli-de-Figueiredo, Isadora Nunes Erthal, Rafaela Siviero Caron-Lienert, Bartira Ercília Pinheiro da Costa, Eduardo Pletsch Brendler, Denise Cantarelli Machado |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cell type CD3 Inflammation Preeclampsia Flow cytometry Th2 Cells Pre-Eclampsia Pregnancy Internal medicine Internal Medicine medicine Humans biology medicine.diagnostic_test business.industry Obstetrics and Gynecology Interleukin Gestational age T-Lymphocytes Helper-Inducer Th1 Cells medicine.disease Endocrinology biology.protein Cytokines Female medicine.symptom business CD8 |
| Zdroj: | Hypertension in Pregnancy. 41:15-22 |
| ISSN: | 1525-6065 1064-1955 |
| DOI: | 10.1080/10641955.2021.2008424 |
| Popis: | To evaluate total Th1/Th2 cytokines in CD3+ cells (immunocompetent T-lymphocytes) and peripheral blood lymphocytes, mostly CD4+ (T helper cells) and CD8+ (T-cytotoxic cells) subpopulations in preeclampsia. Total blood leukocytes and lymphocytes counts, percent cells: CD3+, INF-g+/CD3+, IL-4+/CD3+, and IL-10+/CD3+, CD4+/CD8+ were determined by flow-cytometry. Preeclampsia (n= 26) and normal pregnancy (n= 25) participants were age and gestational age matched. CD4+ lymphocytes count was higher in preeclampsia, compared with normal pregnancy (43.6 ± 5.8 vs 37.6 ± 5.6%; P |
| Databáze: | OpenAIRE |
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