Incidence and pathogenesis of megaloblastic erythropoiesis in multiple myeloma
| Autor: | A. V. Hoffbrand, J. R. Hobbs, D. L. Mollin, S. Kremenchuzky |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Adult
Male medicine.medical_specialty Anemia Folic Acid Deficiency Gastroenterology Intestinal absorption Pathology and Forensic Medicine Pathogenesis Blood serum Folic Acid Internal medicine hemic and lymphatic diseases medicine Humans Erythropoiesis Cyanocobalamin Vitamin B12 Anemia Macrocytic skin and connective tissue diseases Multiple myeloma Aged business.industry Vitamin B 12 Deficiency General Medicine Articles Middle Aged medicine.disease Vitamin B 12 Endocrinology Intestinal Absorption Female sense organs business Multiple Myeloma |
| Zdroj: | Journal of clinical pathology. 20(5) |
| ISSN: | 0021-9746 |
| Popis: | Intermediate megaloblastic changes occurred in six (19%) of 32 patients with multiple myeloma and trivial megaloblastic changes in a further ten (31%). Folate deficiency was the predominant cause of these changes and in at least two patients was sufficiently severe to contribute to anaemia. Folate deficiency appeared to be due to excess folate utilization by the tumour and was related to the amount of paraprotein produced daily. Five of the 32 patients had subnormal serum B(12) levels. Reduction in the serum B(12) level was related to the reduction in the normal circulating immunoglobulins and occurred despite normal B(12) absorption. Possible explanations for this finding are discussed. |
| Databáze: | OpenAIRE |
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