Uropathogenic Escherichia coli Isolates from Pregnant Women in Different Countries
| Autor: | Dang Thi Ngoc Dzung, Musa Sekikubo, Corinna Kosnopfel, Annelie Brauner, Nubia L. Ramos, Florence Mirembe, Fred Kironde |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Microbiology (medical) Adolescent Virulence Factors Virulence Biology medicine.disease_cause Bacterial Adhesion Microbiology Young Adult Antigen Pregnancy Drug Resistance Multiple Bacterial medicine Humans Uropathogenic Escherichia coli Uganda Pregnancy Complications Infectious Young adult Escherichia coli Escherichia coli Infections Phylogeny Sweden Incidence (epidemiology) Epithelial Cells Bacteriology Middle Aged medicine.disease Virology Molecular Typing Multiple drug resistance Vietnam Biofilms Bacterial virulence Female |
| Zdroj: | Journal of Clinical Microbiology. 50:3569-3574 |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.01647-12 |
| Popis: | Urinary tract infection (UTI) is common during pregnancy and can be associated with negative outcomes for both the mother and fetus. Increased risk of infection among these patients has been attributed to physiological changes, and less focus has been placed on Escherichia coli , the most frequent causative agent. We investigated the virulence properties of isolates causing UTI in pregnant women in Sweden, Uganda, and Vietnam, as well as nonpregnant women in Sweden. Although phylogenetic group B2 was the most prevalent group, more Ugandan isolates belonged to group B1, associated with commensal strains, than isolates from other countries. Adherence to and invasion of urothelial cells, key events in the infection process, were low among group B1 isolates from pregnant Swedish women compared to those from nonpregnant patients. Similar levels of adherence and invasion were seen in isolates from pregnant women in Uganda and Vietnam. More biofilm was formed by group B2 isolates than by those belonging to group B1 and by Ugandan group B2 isolates than by those from pregnant Swedish and Vietnamese women. The antigen 43a-encoding gene, fluA CFT073 , was most prevalent among Ugandan isolates. Expression of the biofilm components, curli and cellulose, was low among all isolates. Multidrug resistance was more common among isolates from Uganda and Vietnam than among those from Swedish patients. We suggest that while bacterial virulence properties play an important role in UTI during pregnancy, physiological changes in the host may contribute more to the incidence of infection caused by less virulent E. coli . |
| Databáze: | OpenAIRE |
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