Effects of training and albuterol on pain and fatigue in facioscapulohumeral muscular dystrophy

Autor: Eline Lindeman, Gijs Bleijenberg, E.L. van der Kooi, Jan C.M. Hendriks, Joke S. Kalkman, George W. Padberg, B.G.M. van Engelen
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Male
Neurology
Time Factors
Physical fitness
law.invention
Randomized controlled trial
law
Sickness Impact Profile
Effective Primary Care and Public Health [EBP 3]
Perception and Action [DCN 1]
Facioscapulohumeral muscular dystrophy
Fatigue
Pain Measurement
Human Movement & Fatigue [NCEBP 10]
Original Communication
exercise therapy
Psychological determinants of chronic illness [NCEBP 8]
Adrenergic beta-Agonists
Middle Aged
Combined Modality Therapy
Muscular Dystrophy
Facioscapulohumeral
Female
Functional Neurogenomics [DCN 2]
medicine.drug
Adult
medicine.medical_specialty
Strength training
Clinical Neurology
facioscapulohumeral muscular dystrophy
Pain
Physical exercise
Statistics
Nonparametric
Quality of Care [ONCOL 4]
Physical medicine and rehabilitation
Double-Blind Method
Interventional oncology [UMCN 1.5]
medicine
Humans
Pain Management
Albuterol
Muscle Strength
Exercise
business.industry
medicine.disease
Neuromuscular development and genetic disorders [UMCN 3.1]
Clinical trial
Evaluation of complex medical interventions [NCEBP 2]
Physical Fitness
Salbutamol
Physical therapy
Neurology (clinical)
Microbial pathogenesis and host defense [UMCN 4.1]
business
Zdroj: Journal of Neurology
Journal of Neurology, 254, 7, pp. 931-40
Journal of Neurology, 254, 931-40
ISSN: 1432-1459
0340-5354
Popis: Contains fulltext : 51802.pdf (Publisher’s version ) (Closed access) BACKGROUND : We recently reported a randomised controlled trial on the efficacy of strength training and the beta2-adrenergic agonist albuterol in patients with facioscapulohumeral muscular dystrophy (FSHD). Strength training and albuterol appeared safe interventions with limited positive effect on muscle strength and volume. We concurrently explored the prevalence and the characteristics of pain and fatigue in the participating FSHD patients, because these are probably underreported but clinically relevant symptoms in this disorder. Next, we studied the effects of albuterol and strength training on pain, experienced fatigue, health-related functional status and psychological distress. METHODS : Sixty-five patients were randomised to strength training of elbow flexors and ankle dorsiflexors or non-training. After 26 weeks, albuterol (sustained-release, 8 mg bid) was added in a randomised, double-blind, placebo-controlled design. Outcomes comprised self-reported pain, experienced fatigue, functional status and psychological distress obtained with validated questionnaires at 52 weeks. RESULTS : Eighty percent of patients reported chronic persistent or periodic, multifocal pains. Thirty-four percent of the participants were severely fatigued. Strength training and albuterol failed to have a significant effect on all outcomes. CONCLUSIONS : Pain and fatigue are important features in FSHD. Strength training and albuterol do not have a positive or negative effect on pain, experienced fatigue, functional status and psychological distress.
Databáze: OpenAIRE
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