The individual and combined influence of HIV and hepatitis C virus on dyslipidaemia in a high-risk Hispanic population
| Autor: | Janet E. Forrester, Rhee, Richard K. Sterling, Barbara H. McGovern |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Blood lipids HIV Infections Article Body Mass Index chemistry.chemical_compound Insulin resistance High-density lipoprotein Risk Factors Internal medicine medicine Humans Pharmacology (medical) Triglycerides Dyslipidemias biology Cholesterol business.industry Health Policy Insulin Cholesterol HDL C-reactive protein virus diseases Cholesterol LDL Hispanic or Latino Hepatitis C Hepatitis C Chronic medicine.disease United States Retinol-Binding Proteins C-Reactive Protein Infectious Diseases Endocrinology Anti-Retroviral Agents chemistry Case-Control Studies biology.protein Female lipids (amino acids peptides and proteins) Insulin Resistance business Lipoprotein |
| Zdroj: | HIV Medicine. 10:555-563 |
| ISSN: | 1468-1293 1464-2662 |
| DOI: | 10.1111/j.1468-1293.2009.00722.x |
| Popis: | Objectives To assess the effects of chronic hepatitis C (HCV) and HIV infection on dyslipidaemia in a Hispanic population at high risk of insulin resistance. Methods We compared serum lipids and C-reactive protein (CRP) in 257 Hispanic adults including 47 HIV- mono-infected, 43 HCV-mono-infected and 59 HIV/HCV-co-infected individuals as well as 108 healthy controls. We also assessed the effect of HCV on lipid alterations associated with antiretroviral therapy (ART), and the impact of HCV and HIV on the associations among insulin resistance, triglycerides and cholesterol. Results HCV infection was associated with lower total and low-density lipoprotein (LDL) cholesterol, but not high-density lipoprotein (HDL) cholesterol or triglycerides compared with healthy controls. HIV infection was associated with higher triglycerides and lower HDL, but not total or LDL cholesterol. HCV mitigated the elevation of triglycerides associated with ART. In healthy Hispanic adults, insulin resistance was significantly correlated with higher triglycerides, CRP and lower HDL. HIV infection nullified the association of insulin resistance with triglycerides and HDL, and the association of triglycerides with LDL. HCV infection nullified the association of insulin resistance with triglycerides, HDL and CRP. Conclusions HCV co-infection alters the profile of HIV-associated dyslipidaemia. The clinical significance of these findings for cardiovascular complications in HIV merits further study. |
| Databáze: | OpenAIRE |
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