Copper/Zinc-Superoxide Dismutase in Human Epidermis: An Immunochemical Study
| Autor: | Vincenzo Cimini, Giovanna Giuseppina Altobelli, Susan Van Noorden |
|---|---|
| Přispěvatelé: | Altobelli, Gg, Van Noorden, S, Cimini, V |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cell type
Pathology medicine.medical_specialty 030209 endocrinology & metabolism Human skin densitometry Zn-superoxide dismutase Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Dermis medicine Cu Zn-superoxide dismutase human skin immunochemistry skin tumors densitometry Cu lcsh:R5-920 integumentary system biology Epidermis (botany) Chemistry General Medicine Brief Research Report skin tumors medicine.anatomical_structure Cytoplasm 030220 oncology & carcinogenesis immunochemistry biology.protein Medicine Immunohistochemistry Dismutase human skin lcsh:Medicine (General) |
| Zdroj: | Frontiers in Medicine, Vol 6 (2019) Frontiers in Medicine |
| Popis: | The localization of copper and zinc-superoxide dismutase in normal and neoplastic human skin was examined with immunochemical techniques. Skin samples were taken from males and females of different ages, UV exposed and non-exposed areas and basal-/spino-cellular carcinomas. The enzyme was localized diffusely in the cytoplasm and was also found in the nuclei of epidermal cells, endothelial cells and other dermis cell types. The dismutase content in the epidermis was higher in males than females, UV-exposed than non-exposed and young than old people. In the tumors, the enzyme content of the superficial epidermal layers was higher than in the deep tumoral epithelial cells. These data suggest that the localization of Cu, Zn-SOD in skin tissues reflects the gender and age of the subject, the cell types and their normal or diseased state. Further studies based on the investigation of systemic changes of this enzyme in physiological and pathological epidermis could provide additional information on tumor cell generation. |
| Databáze: | OpenAIRE |
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