| Popis: |
Low protein, high carbohydrate diets can increase lifespan and improve metabolic health in both rodents and humans, but the specific aspects of a low protein diet that promote health and longevity have not been identified. Here, we demonstrate that a specific reduction in dietary branched chain amino acids (BCAAs) is sufficient to improve metabolic health, improving glucose tolerance and decreasing adiposity in both young and middle-aged mice, and promoting leanness and insulin sensitivity in mouse models of diet-induced obesity. Further, we find that diets with decreased protein or BCAA content can promote the longevity of progeroid mice. Reduced consumption of BCAAs does not induce the production of FGF21, a reputed endocrine signal of protein restriction and fasting, but does result in specific inhibition of the mechanistic Target Of Rapamycin Complex 1 (mTORC1). Our results suggest that a reduction in dietary branched chain amino acids promotes metabolic health and longevity, and may represent a highly translatable option for the treatment of diabetes and other age-related diseases. |
