The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory

Autor:	Xiang Li, Michael S. Kobor, Yi E. Sun, Zoran Boskovic, Vikram S. Ratnu, Wei Wei, Carlos M. Coelho, Kevin J. Dudley, Danay Baker-Andresen, Timothy W. Bredy, Quan Lin
Rok vydání:	2011
Předmět:	Male Cell Adhesion Molecules Neuronal Conditioning Classical Nerve Tissue Proteins Transfection CREB Extinction Psychological Potassium Chloride Mice Transduction (genetics) Memory Transduction Genetic Protein Phosphatase 1 microRNA Animals Humans Gene silencing RNA Small Interfering Cyclic AMP Response Element-Binding Protein Gene Cell Line Transformed Extracellular Matrix Proteins Behavior Animal biology General Neuroscience Serine Endopeptidases Brain RNA Fear social sciences Extinction (psychology) humanities Mice Inbred C57BL MicroRNAs Reelin Protein Gene Expression Regulation Trans-Activators biology.protein Neuroscience
Zdroj:	Nature Neuroscience. 14:1115-1117
ISSN:	1546-1726 1097-6256
Popis:	MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85ba938c03babd7ec357927587c17cb https://doi.org/10.1038/nn.2891 Zobrazit plný text záznamu Plný text ve formátu PDF