Ingestion of a Mixed Meal Does Not Affect the Metabolic Clearance Rate of Biosynthetic Human C-Peptide*
| Autor: | B Frank, Kenneth S. Polonsky, B D Given, W. Pugh, Arthur H. Rubenstein, Diane Ostrega, J. Licinio-Paixao |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Calorie Metabolic Clearance Rate Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Biology Mixed meal Biochemistry chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Ingestion Secretion C-Peptide C-peptide Insulin Biochemistry (medical) Metabolism Recombinant Proteins Diet Diabetes Mellitus Type 1 chemistry Female Steady state (chemistry) |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 63:401-403 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-63-2-401 |
| Popis: | The validity of C-peptide as a peripheral marker of insulin secretion during different physiological conditions depends on the demonstration that C-peptide clearance is constant under these circumstances. Recently biosynthetic human C-peptide, identical in structure to pancreatic human C-peptide, became available for use in human subjects. The present study was undertaken to determine if the metabolic clearance of C-peptide was altered by ingestion of a mixed meal. Eight insulin-dependent diabetic patients received constant iv infusions of biosynthetic human C-peptide which raised the plasma C-peptide concentration to a level of 3.8 +/- 0.2 (+/- SEM) pmol/ml. The MCR of C-peptide was 4.5 +/- 0.3 ml/kg X min. After steady state levels of C-peptide had been reached, each patient consumed a 530 calorie mixed meal. The plasma glucose concentration increased from a baseline value of 104.5 +/- 4.8 mg/dl to a 336 +/- 10 mg/dl 150 min later. This change in plasma glucose was not associated with a significant alteration in the plasma C-peptide concentration and the MCR of the infused C-peptide was not affected by meal ingestion (4.5 +/- 0.3 vs. 4.3 +/- 0.3 ml/kg X min). These results therefore support the validity of using C-peptide as a marker for changes in insulin secretion after mixed meals. |
| Databáze: | OpenAIRE |
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