Angiotensinogen, angiotensin II and adipose tissue development
| Autor: | Gérard Ailhaud, Akiyoshi Fukamizu, Florence Massiera, Raymond Negrel, Michèle Teboul, Perla Saint-Marc |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Adipose tissue macrophages Angiotensinogen Medicine (miscellaneous) Adipose tissue Prostacyclin chemistry.chemical_compound Internal medicine Adipocyte parasitic diseases Renin–angiotensin system Adipocytes medicine Humans Obesity Autocrine signalling Nutrition and Dietetics Chemistry Angiotensin II Epoprostenol Endocrinology Adipose Tissue Gene Expression Regulation cardiovascular system hormones hormone substitutes and hormone antagonists Ex vivo circulatory and respiratory physiology medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/sj.ijo.0801501 |
| Popis: | Adipose tissue is an important source of angiotensinogen (AGT). Recent evidence shows that a local renin-angiotensinogen system (RAS) is present in human adipose tissue and may act as a distinct system from plasma RAS. In obese patients, the involvement of angiotensin II (angII) as a consequence of increased plasma AGT secreted from adipose tissue has been proposed in the development of hypertension. Another role of AGT via angII in the development of adipose tissue is supported by the following: (i) in vitro, angII stimulates the production and release of prostacyclin from adipocytes, which in turn promotes the differentiation of precursor cells into adipocytes; (ii) ex vivo and in vivo, both angII and (carba)prostacyclin promote the formation of new fat cells; and (iii) AGT -/- mice exhibit a slowing down of adipose tissue development, as compared to wild-type mice. Altogether the data are consistent with an autocrine/paracrine mechanism implicating AGT, angII and prostacyclin in adipose tissue development. |
| Databáze: | OpenAIRE |
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