A prospective, nonrandomized study of the impact of amifostine on subsequent hypothyroidism in irradiated patients with head and neck cancers
| Autor: | K.S. Clifford Chao, Todd H. Wasserman, Imran Zoberi |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment Thyroid Gland Radiation-Protective Agents Disease Amifostine Clinical Trials Phase II as Topic Hypothyroidism Quality of life medicine Animals Humans Radiology Nuclear Medicine and imaging Radiation Injuries Head and neck business.industry Incidence (epidemiology) Definitive chemoradiotherapy Surgery Clinical trial Radiation therapy Oncology Head and Neck Neoplasms business medicine.drug |
| Zdroj: | Seminars in Radiation Oncology. 12:14-17 |
| ISSN: | 1053-4296 |
| DOI: | 10.1053/srao.2002.31357 |
| Popis: | The daily administration of subcutaneous amifostine to patients with head and neck cancers before each radiation fraction may reduce the long-term incidence of hypothyroidism (HT) after radiotherapy to the neck and may provide an additional indication for amifostine (Ethyol) use. Cancers of the head and neck afflict 40,000 patients yearly in the United States, and radiotherapy plays a pivotal role in the management of at least half of these patients. Patients commonly are treated with radiation alone, combined surgery and radiation, or definitive chemoradiotherapy. Local control of disease is achieved in many patients who are at risk for late sequelae of treatment that may diminish quality of life. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect