A Novel HIV-1 Second-Generation Recombinant Form (CRF01_AE/07_BC) Among Heterosexuals in Nei Monggoi Autonomous Region in China
| Autor: | Xiaoxu Han, Minghui An, Hong Shang, Zhenxing Chu, Bin Zhao, Junjie Xu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine China Lineage (genetic) Genotype Immunology Population Human immunodeficiency virus (HIV) HIV Infections Biology medicine.disease_cause law.invention 03 medical and health sciences 0302 clinical medicine law Virology medicine Humans Public Health Surveillance 030212 general & internal medicine Heterosexuality education Phylogeny Hiv surveillance Recombination Genetic Genetics Molecular Epidemiology education.field_of_study Molecular epidemiology virus diseases Middle Aged 030104 developmental biology Infectious Diseases HIV-1 Recombinant DNA Female |
| Zdroj: | AIDS Research and Human Retroviruses. 32:818-821 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | Increasing second-generation recombinant forms (CRF01_AE/07_BC) have been detected in China recently. Here, we isolated a novel CRF01_AE/07_BC second-generation recombinant form in HIV-1-positive Nei Monggoi's heterosexuals with one CRF07_BC inserted into the CRF01_AE backbone. Polygenetic analyses showed that the CRF01_AE region was grouped with the previously reported cluster 5 lineage, which spreads among the sexual population in north of China, inferring that this recombinant event occurred through heterosexual contact in the north of China possibly. The growing emergence of recombinant forms means coexistence of multiple strains and complexity of the HIV-1 epidemic, which reminds us of the urgent necessity to focus the HIV surveillance among the high-risk populations nationwide in China, particularly to enhance preventive measures in HIV-1 low-prevalence areas. |
| Databáze: | OpenAIRE |
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