Gastric anti-secretory and anti-ulcerogenic effects of Dombeya buettneri in rats
| Autor: | B.A Akpogomeh, R.R Ettarh, Mbeh U. Eteng, O.O Okwari |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Pharmacology Gastroenterology law.invention Gastric Acid chemistry.chemical_compound law Internal medicine Drug Discovery Gastric mucosa medicine Animals Secretion Stomach Ulcer Rats Wistar Plants Medicinal Ethanol business.industry Stomach Anti-ulcer Agent digestive oral and skin physiology Anti-Ulcer Agents Mucus digestive system diseases Rats medicine.anatomical_structure chemistry Gastric Mucosa Gastric acid business Phytotherapy Histamine |
| Zdroj: | Journal of ethnopharmacology. 71(1-2) |
| ISSN: | 0378-8741 |
| Popis: | The effects of an aqueous extract of the leaves of Dombeya buettneri on gastric acid secretion and ethanol-induced gastric mucosal damage were studied in rats. Gastric acid secretion was measured by continuous perfusion in urethane-anaesthetised rats. Intragastric perfusion with the extract caused significant reduction in basal and histamine-stimulated gastric acid secretion. Pretreatment with the extract also reduced the extent of gastric mucosal damage induced by oral ethanol (75% v/v), but had no effect on mucus secretion. It is suggested that the consumption of an extract of the leaves of D. buettneri may be beneficial in the prevention and treatment of peptic ulcer disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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