Early diagnosis of mortality using admission CT perfusion in severe traumatic brain injury patients (ACT-TBI): protocol for a prospective cohort study
| Autor: | Rob Grierson, Murdoch Leeies, Anurag Trivedi, Divjeet Batoo, Sudharsana R. Ande, Frederick A. Zeiler, Jai Jai Shiva Shankar, Marco Essig, Namita Sinha, Susan Alcock, Douglas Martin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Canada Traumatic brain injury Population Perfusion scanning Physical examination 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Brain Injuries Traumatic accident & emergency medicine Medicine Humans neuroradiology Glasgow Coma Scale Prospective Studies neurosurgery education Prospective cohort study Neuroradiology education.field_of_study medicine.diagnostic_test business.industry Radiology and Imaging computed tomography General Medicine medicine.disease 3. Good health Perfusion Early Diagnosis nervous system Emergency medicine Neurosurgery business Tomography X-Ray Computed 030217 neurology & neurosurgery |
| Zdroj: | BMJ Open BMJ Open, Vol 11, Iss 6 (2021) |
| ISSN: | 2044-6055 |
| Popis: | IntroductionSevere traumatic brain injury (TBI) is a catastrophic neurological condition with significant economic burden. Early in-hospital mortality (Methods and analysisThe Early Diagnosis of Mortality using Admission CT Perfusion in Severe Traumatic Brain Injury Patients study, is a prospective cohort study in patients with severe TBI funded by a grant from the Canadian Institute of Health Research. Adults aged 18 or older, with evidence of a severe TBI (Glasgow Coma Scale score ≤8 before initial resuscitation) and, on mechanical ventilation at the time of imaging are eligible. Patients will undergo CTP at the time of first imaging on their hospital admission. Admission CTP compares with the reference standard of an accepted bedside clinical assessment for brainstem function. Deferred consent will be used. The primary outcome is a binary outcome of mortality (dead) or survival (not dead) in the first 48 hours of admission. The planned sample size for achieving a sensitivity of 75% and a specificity of 95% with a CI of ±5% is 200 patients.Ethics and disseminationThis study has been approved by the University of Manitoba Health Research Ethics Board. The findings from our study will be disseminated through peer-reviewed journals and presentations at local rounds, national and international conferences. The public will be informed through forums at the end of the study.Trial registration numberNCT04318665 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|