Closing the structure-to-function gap for LRRK2
| Autor: | Valerie Tokars, Chuyu Chen, Loukia Parisiadou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
LRRK2 Gene
Parkinson's disease Structure (category theory) Parkinson Disease Computational biology Biology medicine.disease Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Biochemistry LRRK2 nervous system diseases Mutation medicine LRRK2 Protein Humans Closing (morphology) Molecular Biology Function (biology) |
| Zdroj: | Trends in biochemical sciences. 47(3) |
| ISSN: | 0968-0004 |
| Popis: | Variations in the LRRK2 gene represent one of the strongest genetic factors for Parkinson's disease (PD). It has become clear that structural knowledge of the encoded large multidomain LRRK2 protein will cast light on its biological function. The new study from Myasnikov, Zhu, et al. provides a high-resolution structure of the full-length LRRK2. |
| Databáze: | OpenAIRE |
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