Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats
| Autor: | Nils Wierup, Andreas Lindqvist, Monica Sandberg, Peter Spégel |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male endocrine system medicine.medical_specialty Physiology Glucose uptake Metabolite medicine.medical_treatment Clinical Biochemistry Blood sugar Gastric Inhibitory Polypeptide Ketone Bodies Type 2 diabetes Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Blood serum Rats Inbred SHR Internal medicine medicine Animals Insulin Lipid metabolism medicine.disease Rats chemistry Hyperglycemia Ketone bodies Amino Acids Branched-Chain hormones hormone substitutes and hormone antagonists |
| Zdroj: | Regulatory Peptides. 189:11-16 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/j.regpep.2013.12.009 |
| Popis: | Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance. Besides its insulinotropic effect, GIP also directly affects glucose uptake and lipid metabolism. This notwithstanding, effects of GIP on other circulating metabolites than glucose have not been thoroughly investigated. Here, we examined effects of infusion of various concentrations of GIP in normo- and hyperglycemic rats on serum metabolite profiles. We found that, despite a decrease in serum glucose levels (-26%, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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