Prenatal and concurrent cocaine, alcohol, marijuana, and tobacco effects on adolescent cognition and attention
Autor: | Lynn T. Singer, Sonia Minnes, Elizabeth J. Short, Barbara A. Lewis, Miaoping Wu, Meeyoung O. Min, Adelaide Lang |
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Rok vydání: | 2018 |
Předmět: |
Pharmacology
Longitudinal study biology business.industry 030508 substance abuse Wechsler Adult Intelligence Scale Cognition Toxicology biology.organism_classification Executive functions medicine.disease Article Auditory Continuous Performance Test Substance abuse 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine medicine Pharmacology (medical) Cannabis 0305 other medical science business Neurocognitive 030217 neurology & neurosurgery Clinical psychology |
Zdroj: | Drug Alcohol Depend |
ISSN: | 0376-8716 |
Popis: | Background Prenatal cocaine/polydrug exposure (PCE) may increase vulnerability to substance use disorders due to associated cognitive deficits. We examined whether neurocognitive deficits in executive functions and attention observed in PCE children persisted to adolescence when compared to non-cocaine/polydrug (NCE) children, and whether adolescent substance use (tobacco, alcohol, marijuana) was also associated with neurocognitive deficits. Methods 354 (180 PCE, 174 NCE) adolescents in a longitudinal study from birth were administered the Wechsler Intelligence Scales for Children - IV (WISC-IV), and the Integrated Visual and Auditory Continuous Performance Test (IVA/CPT) at age 15.5. Assessments of prenatal exposure to cocaine, alcohol, marijuana, and tobacco and measures of use at age 15.5 were taken. Confounding factors measured included lead, the caregiving environment, and violence exposure. Relationships between drug use and prenatal exposures on outcomes were assessed through multiple regression. Results Adolescents with PCE had deficits in Perceptual Reasoning IQ and visual attention. Prenatal alcohol exposure predicted verbal and working memory IQ and visual and auditory attention deficits. Adolescent tobacco, alcohol, and marijuana use predicted attention in addition to PCE, lead and the caregiving environment. Conclusion Prenatal cocaine and alcohol exposure and adolescent use of substances are associated with neurocognitive deficits known to increase vulnerability to SUDs. |
Databáze: | OpenAIRE |
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