Low-dose omeprazole plus clarithromycin and either tinidazole or amoxycillin for Helicobacter pylori infection
| Autor: | Lucio Cuoco, Massimo Montalto, F Trua, Giovanni Gasbarrini, Antonio Tursi, Giovanna Branca, Giovanni Cammarota, Giuseppe Fedeli, G Veneto, Alfredo Papa |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Rapid urease test Proton-pump inhibitor Gastroenterology Tinidazole Group B Helicobacter Infections Clarithromycin Internal medicine medicine Humans Pharmacology (medical) Prospective Studies Dyspepsia Omeprazole Aged Antibacterial agent Helicobacter pylori Hepatology biology business.industry Amoxicillin Drug Resistance Microbial Middle Aged Anti-Ulcer Agents biology.organism_classification Anti-Bacterial Agents Surgery Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 10:285-288 |
| ISSN: | 0269-2813 |
| DOI: | 10.1111/j.0953-0673.1996.00285.x |
| Popis: | BACKGROUND: The aim of our study was to compare two 1-week, low-dose triple therapies for Helicobacter pylori eradication. METHODS: One hundred consecutive patients, suffering from dyspeptic symptoms with H. pylori infection, were randomly allocated to 7 days of treatment with omeprazole 20 mg o.m. plus clarithromycin 250 mg b.d. and either tinidazole 500 mg b.d. (group A: n = 50, 19 with peptic ulcer) or amoxycillin 1000 mg b.d. (group B: n = 50, 20 with peptic ulcer). H. pylori-status was evaluated by means of histology, culture and urease test, at entry and 8 weeks after treatment. RESULTS: Three patients did not complete the treatment. H. pylori eradication was obtained in 35 patients from group A (73%) (95% CI, 55-82%) and in 40 patients from group B (82%) (95% CI, 66-90%). On intention-to-treat analysis, the rates of eradication were similar. Side-effects occurred in seven patients from group A (14.58%) and in four patients from group B (8.33%), but none discontinued therapy because of side-effects. CONCLUSION: Both triple 1-week, low-dose omeprazole therapies gave good eradication rates with infrequent side-effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text