BMP6-induced modulation of the tumor micro-milieu
| Autor: | Lena Feuerer, David Stieglitz, Bernd Echtenacher, Claus Hellerbrand, Sigrid Karrer, Simone Braig, Anja-Katrin Bosserhoff, Peter Dietrich, Stephanie Arndt, Susanne Lamm, Silke Kuphal |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Cancer Research Skin Neoplasms Bone Morphogenetic Protein 6 Mice Transgenic Biology Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Tumor Microenvironment Genetics medicine Animals Humans Melanoma neoplasms Molecular Biology Tumor microenvironment Neoplasms Experimental Mast cell medicine.disease Neoplasm Proteins Bone morphogenetic protein 6 030104 developmental biology medicine.anatomical_structure Tumor progression Cell culture 030220 oncology & carcinogenesis Cancer research Experimental pathology Female Skin cancer |
| Zdroj: | Oncogene. 38:609-621 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/s41388-018-0475-x |
| Popis: | Melanoma is the deadliest form of skin cancer with rising incidence, creating a significant health problem. We discovered increased expression of bone morphogenetic protein 6 (BMP6) in melanoma cells and tissues, and observed that BMP6 deficiency caused significantly delayed tumor onset and decelerated tumor progression in a melanoma mouse model. Moreover, we determined that BMP6 inhibits dermal mast cell recruitment and found that mast cell-derived mediators significantly reduced melanoma growth in vitro. In line with this, mast cell deficiency accelerated tumor onset and progression in a melanoma mouse model. Analysis of human melanoma tissues revealed a strong negative correlation between melanoma proliferation and mast cell infiltration. This study elucidates a novel role of BMP6-induced modulation of the tumor microenvironment. |
| Databáze: | OpenAIRE |
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