Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles
| Autor: | Sandrine Guillou, Mikhail S. Ermolenko, Yves L. Janin |
|---|---|
| Přispěvatelé: | Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Chimie organique (CNR - UMR3523), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Region Ile de France I 06-222/R I 09-1739/R, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie organique (CNRS - UMR3523), Institut Pasteur [Paris] (IP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Trifluoromethyl
010405 organic chemistry Negishi coupling [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry Pyrazole 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Hydrolysis chemistry Drug Discovery Organic chemistry Derivative (chemistry) Building blocks 3/5-Trifluoromethylpyrazoles Pyrazole-3/5-carboxylic acids Cross-coupling Palladium catalysis |
| Zdroj: | Tetrahedron Tetrahedron, Elsevier, 2013, 69 (1), pp.257-263. ⟨10.1016/j.tet.2012.10.034⟩ Tetrahedron, 2013, 69 (1), pp.257-263. ⟨10.1016/j.tet.2012.10.034⟩ |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2012.10.034⟩ |
| Popis: | International audience; We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of SuzukieMiyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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