On-beam synchrony in the cerebellum as the mechanism for the timing and coordination of movement
| Autor: | Detlef H. Heck, William T. Thach, J. G. Keating |
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| Rok vydání: | 2007 |
| Předmět: |
Physics
Cerebellum Time Factors Multidisciplinary Behavior Animal Quantitative Biology::Neurons and Cognition Movement (music) Extramural Movement Quantitative Biology::Tissues and Organs Purkinje cell Anatomy Biological Sciences Rats sprague dawley Rats Rats Sprague-Dawley Sprague dawley Mechanism (engineering) medicine.anatomical_structure medicine Animals Physics::Accelerator Physics Neuroscience Beam (structure) |
| Zdroj: | Proceedings of the National Academy of Sciences. 104:7658-7663 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0609966104 |
| Popis: | In trained reaching rats, we recorded simple spikes of pairs of Purkinje cells that, with respect to each other, were either aligned on a beam of shared parallel fibers or instead were located off beam. Rates of simple spike firing in both on-beam and off-beam Purkinje cell pairs commonly showed great variety in depth of modulation during reaching behavior. But with respect to timing, on-beam Purkinje cell pairs had simple spikes that were tightly time-locked to each other (either delayed or simultaneous) and to movement, despite the variability in rate. By contrast, off-beam Purkinje cell pairs had simple spikes that were not time-locked to each other, neither delayed nor simultaneous. We discuss the implications of these observations for the cerebellar role in timing and coordinating movement. |
| Databáze: | OpenAIRE |
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