Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
Autor: | Ruifeng Luo, Jinming Zhang, Ziyi Xu, Chen Zhang, Jiaxin Li, Jin-Feng Shi, Liang Chen, Chaomei Fu, Fei Gao |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Combination therapy Review combination therapy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Pharmacology (medical) celastrol Pharmacology Therapeutic window biology business.industry analogs of celastrol lcsh:RM1-950 biology.organism_classification Cancer treatment anticancer activity lcsh:Therapeutics. Pharmacology 030104 developmental biology chemistry Celastrol 030220 oncology & carcinogenesis Drug delivery Cancer research nano/micro-formulation Tripterygium wilfordii business |
Zdroj: | Frontiers in Pharmacology, Vol 11 (2020) Frontiers in Pharmacology |
ISSN: | 1663-9812 |
Popis: | Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits significant broad-spectrum anticancer activities for the treatment of a variety of cancers including liver cancer, breast cancer, prostate tumor, multiple myeloma, glioma, etc. However, the poor water stability, low bioavailability, narrow therapeutic window, and undesired side effects greatly limit its clinical application. To address this issue, some strategies were employed to improve the anticancer efficacy and reduce the side-effects of celastrol. The present review comprehensively focuses on the various challenges associated with the anticancer efficiency and drug delivery of celastrol, and the useful approaches including combination therapy, structural derivatives and nano/micro-systems development. The specific advantages for the use of celastrol mediated by these strategies are presented. Moreover, the challenges and future research directions are also discussed. Based on this review, it would provide a reference to develop a natural anticancer compound for cancer treatment. |
Databáze: | OpenAIRE |
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