Characterization of a novel staphylococcal cassette chromosome composite island from community-associated MRSA isolated in aged care facilities in Western Australia
| Autor: | Geoffrey W. Coombs, L. Wilson, Warren B. Grubb, Frances G. O'Brien, K. Christiansen |
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| Rok vydání: | 2016 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
0301 basic medicine Microbiology (medical) medicine.medical_specialty Meticillin Genomic Islands Genotype 030106 microbiology Virulence Biology medicine.disease_cause Microbiology Evolution Molecular 03 medical and health sciences Antibiotic resistance Molecular genetics medicine Homes for the Aged Humans Pharmacology (medical) Aged Recombination Genetic Pharmacology SCCmec Chromosome Western Australia Chromosomes Bacterial Staphylococcal Infections biochemical phenomena metabolism and nutrition Methicillin-resistant Staphylococcus aureus Nursing Homes Community-Acquired Infections stomatognathic diseases 030104 developmental biology Infectious Diseases Mobile genetic elements medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 71:3372-3375 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/dkw317 |
| Popis: | Background: In Western Australia (WA), clonal complex 5, ST835, community-associated (CA) MRSA is isolated almost exclusively from aged care facilities. In WA four different staphylococcal cassette chromosome (SCC) mec (SCCmec) elements have been identified in this ST, indicating high genetic activity in the SCCmec region. Objectives: To investigate the SCC region of ST835 CA-MRSAWA MRSA-40 and determine the distribution of an SCCsorbitol element found within the region. Results: The SCC region contained a composite island, SCCmec(WA MRSA-40)-CI, that was composed of three elements, Psi SCCpls, SCCsorbitol and SCCmecV(T) (5C2&5). This is the first time that a sorbitol operon has been reported in an SCC element. Conclusions: Generation of SCCmecWA MRSA-40-CI has involved multiple genetic events and recombination with CoNS has occurred during evolution of the SCC elements. While Staphylococcus aureus is renowned for its ability to utilize mobile genetic elements to disseminate antimicrobial resistance, the SCC region of WA MRSA-40 shows that this clone has also utilized SCC elements to acquire extra virulence and possibly adapt to a niche environment. |
| Databáze: | OpenAIRE |
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