Monosodium Glutamate Reduces 68Ga-PSMA-11 Uptake in Salivary Glands and Kidneys in a Preclinical Prostate Cancer Model
| Autor: | Kuo-Shyan Lin, Navjit Hundal-Jabal, Joseph Lau, Etienne Rousseau, Nadine Colpo, Helen Merkens, Hsiou-Ting Kuo, Zhengxing Zhang, Francois Benard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Glutamate Carboxypeptidase II
Male Monosodium glutamate medicine.medical_treatment salivary glands Mice SCID Theranostic Nanomedicine 030218 nuclear medicine & medical imaging 68Ga-PSMA-11 Prostate cancer chemistry.chemical_compound prostate-specific membrane antigen Mice 0302 clinical medicine Mice Inbred NOD Positron Emission Tomography Computed Tomography Sodium Glutamate Tissue Distribution Saline Gallium Isotopes Kidney 3. Good health medicine.anatomical_structure 030220 oncology & carcinogenesis Antigens Surface Oligopeptides Biodistribution medicine.medical_specialty kidney Biological Transport Active Gallium Radioisotopes Radiation-Protective Agents 03 medical and health sciences Internal medicine Cell Line Tumor LNCaP medicine Animals Humans Radiology Nuclear Medicine and imaging Basic Edetic Acid Membrane antigen business.industry monosodium glutamate Prostatic Neoplasms medicine.disease Theranostics Endocrinology chemistry Radiopharmaceuticals business |
| Zdroj: | Journal of Nuclear Medicine |
| ISSN: | 1535-5667 0161-5505 |
| Popis: | We evaluated the ability of monosodium glutamate (MSG) to reduce salivary and kidney uptake of a prostate-specific membrane antigen (PSMA) radioligand without affecting tumor uptake. Methods: LNCaP tumor–bearing mice were intraperitoneally injected with MSG (657, 329, or 164 mg/kg) or phosphate-buffered saline (PBS). Fifteen minutes later, the mice were intravenously administered 68Ga-PSMA-11. PET/CT imaging and biodistribution studies were performed 1 h after administration. Results: Tumor uptake (percentage injected dose per gram [%ID]) was not statistically different between groups, at 8.42 ± 1.40 %ID in the 657 mg/kg group, 7.19 ± 0.86 %ID in the 329 mg/kg group, 8.20 ± 2.44 %ID in the 164 mg/kg group, and 8.67 ± 1.97 %ID in the PBS group. Kidney uptake was significantly lower in the 657 mg/kg group (85.8 ± 24.2 %ID) than in the 329 mg/kg (159 ± 26.2 %ID), 164 mg/kg (211 ± 27.4 %ID), and PBS groups (182 ± 33.5 %ID) (P < 0.001). Salivary gland uptake was lower in the 657 mg/kg (3.72 ± 2.12 %ID) and 329 mg/kg (5.74 ± 0.62 %ID) groups than in the PBS group (10.04 ± 2.52 %ID) (P < 0.01). Conclusion: MSG decreased salivary and kidney uptake of 68Ga-PSMA-11 in a dose-dependent manner, whereas tumor uptake was unaffected. |
| Databáze: | OpenAIRE |
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