Botulinum toxin for benign essential blepharospasm: A systematic review and an algorithmic approach
| Autor: | Youssef A Rayess, Samer Jabbour, Marwan Nasr, Cyril J Awaida, F.H. Sleilati, Anthony Ballan, S.M. Abou Zeid |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Essential Blepharospasm business.industry Blepharospasm Botulinum toxin injection Dermatology Botulinum toxin eye diseases 03 medical and health sciences 0302 clinical medicine Neurology Ptosis medicine Humans 030212 general & internal medicine Neurology (clinical) medicine.symptom Botulinum Toxins Type A Onabotulinumtoxin a Medline database business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Revue neurologique. 177(1-2) |
| ISSN: | 0035-3787 |
| Popis: | Summary Background Currently, there is no standardised approach for benign essential blepharospasm treatment with botulinum toxin, and controversies still exist regarding this subject. Objective The objective of this systematic review is to summarise and compare all the published data regarding benign essential blepharospasm treatment with botulinum toxin. Methods On October 3, 2018, an online search of the Medline database was conducted. All articles with a detailed description of their botulinum toxin injection technique for benign essential blepharospasm were included in this review. Results Five studies were selected for inclusion with a total of 854 patients. Four of the included studies used onabotulinumtoxin A and one study used abobotulinumtoxin A. All studies injected the pretarsal orbicularis occuli muscle. The preseptal orbicularis occuli was injected in four studies, and the preorbital muscle in three studies. The most commonly used method of evaluation was the Jankovic Rating Scale. Adverse events were transient, and dose related. Ptosis was more frequently encountered with the preseptal orbicularis injections. Conclusion Botulinum toxin injection for benign essential blepharospasm is a non-invasive and safe procedure. The pretarsal muscle should be considered as the key component when treating benign essential blepharospasm with botulinum toxin. We developed an algorithmic approach to the treatment of benign essential blepharospasm with botulinum toxin. However, further randomised controlled trials are warranted. |
| Databáze: | OpenAIRE |
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