Hyperparathyroidism during pregnancy and the effect of rising calcium on pregnancy loss: a call for earlier intervention
| Autor: | Douglas Politz, Laura Politz, James Norman |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Parathyroidectomy medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Abortion Miscarriage Young Adult Endocrinology Pregnancy Internal medicine Humans Medicine Young adult Retrospective Studies Gynecology Hyperparathyroidism business.industry Incidence (epidemiology) medicine.disease Abortion Spontaneous Gestation Calcium Female business Follow-Up Studies |
| Zdroj: | Clinical Endocrinology. 71:104-109 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.2008.03495.x |
| Popis: | Summary Introduction Hyperparathyroidism (HPT) during pregnancy is rare but poses a significant danger to mother and baby yet the incidence of pregnancy loss and its relationship to the degree of calcium elevation is not known. Design A retrospective patient series from a single practice examined the past and current obstetrical histories of pregnant patients with primary HPT. Results Over a period of 6-years, 32 women age ranging from 19 to 40 years had a total of 77 pregnancies while having elevated serum calcium levels because of primary HPT (incidence 0·7% of all women with primary HPT). Fifteen patients underwent parathyroidectomy during the second trimester resulting in an uneventful delivery of a healthy infant between 36 and 40 weeks gestation. There were no maternal or infant complications at surgery or during the subsequent delivery. Thirty of the remaining 62 pregnancies (48%) were lost, a rate that is 3·5-fold higher than expected (P |
| Databáze: | OpenAIRE |
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