The importance of the chemical state of 99mTc radiopharmaceuticals: an effective tumor imaging form of 99mTc bleomycin
| Autor: | Yoshiaki Terauchi, Teruo Odori, Akira Yokoyama, Yoshihiro Saito, Toru Mori, Kanji Torizuka, Kazuko Horiuchi, Syuzo Okumura, Hisashi Tanaka, Rikushi Morita |
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| Rok vydání: | 1978 |
| Předmět: |
Chemical Phenomena
Stereochemistry Bleomycin Mice chemistry.chemical_compound Neoplasms Animals Technology Pharmaceutical Tissue Distribution Radiology Nuclear Medicine and imaging Carcinoma Ehrlich Tumor Radionuclide Imaging Tumor imaging Radiation Chemistry Radiochemistry Technetium State (functional analysis) Hydrogen-Ion Concentration Chemical state Nuclear Energy and Engineering Tin Isotope Labeling Oxidation-Reduction |
| Zdroj: | The International Journal of Applied Radiation and Isotopes. 29:549-555 |
| ISSN: | 0020-708X |
| DOI: | 10.1016/0020-708x(78)90165-5 |
| Popis: | 99 m Tc-labeled bleomycin ( 99 m Tc-BLM) has been introduced as a tumor-imaging agent. Nevertheless, this complex has been misjudged and its value for clinical use has received no proper evaluation. Various 99 m Tc-BLM species labeled with 99 m Tc in different chemical states are produced depending upon the labeling conditions such as the concentrations of BLM and SnCl 2 , pH and reaction time. As a consequence, their biological behavior is found to be markedly affected by the state of 99 m Tc in the labeled compound administered. Detailed studies of the labeling reactions lead us to conclude that of the complexes tested, a 99 m Tc-BLM complex in which tetravalent 99 m Tc is coordinated through three nitrogen atoms of BLM, is considered to be a valuable one for clinical use. This 99 m Tc species is chemically the most stable and a rapid clearance from blood is obtained; yielding a high tumor-blood ratio of 99 m Tc activity after injection into tumor-bearing mice. A selective labeling method for this 99 m Tc complex is described. |
| Databáze: | OpenAIRE |
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