The tuberculin skin test in relation to immunological in vitro reactions in BCG-vaccinated healthcare workers
| Autor: | L.O. Larsson, M. Ridell, H. Fjällbrant |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Tuberculosis Health Personnel Matched-Pair Analysis Tuberculin Enzyme-Linked Immunosorbent Assay In Vitro Techniques Lymphocyte Activation Peripheral blood mononuclear cell Mycobacterium tuberculosis Interferon-gamma Immune system Predictive Value of Tests medicine Humans Tuberculina Sweden biology business.industry Tuberculin Test Incidence (epidemiology) Incidence Middle Aged bacterial infections and mycoses biology.organism_classification medicine.disease Vaccination Immunology BCG Vaccine Female business |
| Zdroj: | The European respiratory journal. 18(2) |
| ISSN: | 0903-1936 |
| Popis: | The aim was to study the tuberculin skin test in relation to immunologicalin vitroreactions in bacille Calmette-Guérin (BCG)-vaccinated healthcare workers.The present study was performed in Sweden, a country with a low incidence of tuberculosis, a high BCG vaccination efficacy and high tuberculin conversion rates. BCG-vaccinated healthcare workers (n=381) were tuberculin skin tested. From these, 11 subjects with negative tuberculin reactions (in vitroof peripheral blood mononuclear cells with tuberculin purified protein derivative, heat-killed tubercle bacilli and a culture filtrate from tubercle bacilli.In the tuberculin-positive group the lymphocyte transformation response was 2–3 times larger, and IFN-γ production was 7–10 times larger, than in the tuberculin-negative group (pThe present results suggest that a positive tuberculin skin test in bacille Calmette-Guérin-vaccinated subjects indicates a stronger immune response of the protective T-helper 1-type than does a negative test. In similar settings, the study supports the traditional practice of regarding the tuberculin skin test in bacille Calmette-Guérin-vaccinated subjects as an indicator of a protective immune response against tuberculosis. |
| Databáze: | OpenAIRE |
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