Molecular targets in cerebral malaria for developing novel therapeutic strategies
| Autor: | Uday Krishna Baruah, Ravisankar Vanka, Simhadri Praveen Kumar, Phanithi Prakash Babu, Venkata Prasuja Nakka |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Programmed cell death Malaria Cerebral Inflammation Disease Brain damage Bioinformatics 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Coma Neurons business.industry General Neuroscience Mortality rate medicine.disease Disease Models Animal 030104 developmental biology Cerebral Malaria Blood-Brain Barrier Brain Injuries medicine.symptom business 030217 neurology & neurosurgery Malaria |
| Zdroj: | Brain research bulletin. 157 |
| ISSN: | 1873-2747 |
| Popis: | Cerebral malaria (CM) is the severe neurological complication associated with Plasmodium falciparum infection. In clinical settings CM is predominantly characterized by fever, epileptic seizures, and asexual forms of parasite on blood smears, coma and even death. Cognitive impairment in the children and adults even after survival is one of the striking consequences of CM. Poor diagnosis often leads to inappropriate malaria therapy which in turn progress into a severe form of disease. Activation of multiple cell death pathways such as Inflammation, oxidative stress, apoptosis and disruption of blood brain barrier (BBB) plays critical role in the pathogenesis of CM and secondary brain damage. Thus, understanding such mechanisms of neuronal cell death might help to identify potential molecular targets for CM. Mitigation strategies for mortality rate and long-term cognitive deficits caused by existing anti-malarial drugs still remains a valid research question to ask. In this review, we discuss in detail about critical neuronal cell death mechanisms and the overall significance of adjunctive therapy with recent trends, which provides better insight towards establishing newer therapeutic strategies for CM. |
| Databáze: | OpenAIRE |
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