Immunosenescence – the role in the immunotherapy of older population
| Autor: | M Prcina, M Novak, E Kontsekova, V Cigankova |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging Economics and Econometrics Immunosenescence medicine.medical_treatment Autoimmune Diseases Older population 03 medical and health sciences Immune system Neoplasms Materials Chemistry Media Technology Humans Medicine business.industry Repertoire Vaccination Neurodegenerative Diseases Forestry Immunotherapy 030104 developmental biology Ageing Immunology bacteria business Older people |
| Zdroj: | Bratislava Medical Journal. 119:217-220 |
| ISSN: | 1336-0345 |
| DOI: | 10.4149/bll_2018_040 |
| Popis: | With ageing of their populations, many societies are challenged with serious systemic diseases. One of the causes of these diseases could be the age-related defects in immune system termed immunosenescence. Immunosenescence is characterized by accumulation of memory and non-functional immune cells, impaired signalling due to restricted repertoire of receptors, overall pro-inflammatory environment and complete dysregulation of the immune system. Consequences of immunosenescence are serious, older people are not able to respond to new stimuli, including infections and vaccinations and are more prone to oncologic, neurodegenerative and autoimmune diseases (Ref. 49). |
| Databáze: | OpenAIRE |
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