Neurodevelopmental outcomes in children with prenatally diagnosed corpus callosal abnormalities
| Autor: | Mi-Young Lee, Jae-Yoon Shim, Tae-Sung Ko, Mi-Sun Yum, Hyo-Kyoung Park, Hye-Sung Won, Hyun Jin Kim, Hye-Ryun Yeh |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Prenatal diagnosis Corpus callosum Bayley Scales of Infant Development Ultrasonography Prenatal Corpus Callosum 03 medical and health sciences Child Development 0302 clinical medicine Developmental Neuroscience medicine Humans Global developmental delay 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Infant Magnetic resonance imaging General Medicine Odds ratio medicine.disease Magnetic Resonance Imaging Hypoplasia Neurodevelopmental Disorders Child Preschool Agenesis Pediatrics Perinatology and Child Health Female Neurology (clinical) Agenesis of Corpus Callosum business 030217 neurology & neurosurgery |
| Zdroj: | Brain and Development. 40:634-641 |
| ISSN: | 0387-7604 |
| DOI: | 10.1016/j.braindev.2018.04.012 |
| Popis: | Objective Although corpus callosal abnormalities are among the most common brain malformations detected prenatally, few previous studies have described the neurodevelopmental outcomes of children with this condition. The aim of our study was to evaluate the neurodevelopmental outcomes and associated clinical features of children with corpus callosal abnormalities diagnosed by prenatal ultrasonography. Methods Between July 2011 and July 2016, forty-nine children with corpus callosal abnormalities were born in Asan Medical Center Children’s Hospital. Neurodevelopmental assessments were conducted in 40 patients at a median age of 24.8 months using the Bayley Scales of Infant Development II or the Korean Infant and Child Development Test. Patients were categorized according to their postnatal magnetic resonance imaging (MRI) findings and accompanying anomalies. Baseline characteristics and developmental outcomes of each group were compared. Results Isolated agenesis or hypoplasia of the corpus callosum was found in 16 (32.7%) patients, other associated central nervous system (CNS) abnormalities were found in 28 (57.1%) patients, and non-CNS abnormalities were found in 11 (22.4%) patients. Among the 40 patients who underwent developmental assessment, 18 (45.0%) showed normal development and 10 (25.0%) showed moderate-to-severe global developmental delay. Seven of the twelve (58.3%) patients with isolated corpus callosal abnormalities showed normal development. The combination of corpus callosal abnormalities with non-CNS anomalies was significantly associated with developmental delay (odds ratio 2.5, 95% confidence interval 1.6–3.9, p = 0.001). Conversely, children with isolated corpus callosal abnormalities showed relatively favorable neurodevelopmental outcomes. Conclusion Appropriate evaluation and comprehensive therapeutic approaches are strongly recommended for neonates who present with corpus callosal abnormalities combined with additional anomalies. |
| Databáze: | OpenAIRE |
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