Peripapillary Perfused Capillary Density in Acute Angle-Closure Glaucoma: An Optical Coherence Tomography Angiography Study
| Autor: | Masoud Aghsaei Fard, Purit Petpiroon, Chaiwat Teekhasaenee, Apichat Tantraworasin, Yanin Suwan, Wasu Supakontanasan, Rotjaporn Pruksacholavit, Robert Ritch |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Intraocular pressure genetic structures Optic Disk Glaucoma 03 medical and health sciences 0302 clinical medicine Ophthalmology Medicine Humans Prospective Studies Intraocular Pressure business.industry Confounding Angiography Retinal Vessels General Medicine Optical coherence tomography angiography medicine.disease eye diseases Confidence interval Cross-Sectional Studies Capillary density Acute angle-closure glaucoma 030221 ophthalmology & optometry Optic nerve sense organs Visual Fields business Glaucoma Angle-Closure 030217 neurology & neurosurgery Glaucoma Open-Angle Tomography Optical Coherence |
| Zdroj: | Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). 10(2) |
| ISSN: | 2162-0989 |
| Popis: | Purpose To compare peripapillary perfused capillary density (PCD) on optical coherence tomography angiography among resolved acute angle-closure (AAC), primary open-angle glaucoma (POAG), and control eyes. Design Prospective, cross-sectional, observational study. Methods All patients with resolved AAC or POAG of varying severity and controls were enrolled. We obtained 4.5 × 4.5 mm2 optical coherence tomography angiography images of the optic nerve head. PCD was analyzed using customized software with major vessel removal. Continuous variables were assessed using the analysis of variance and Bonferroni correction test. A marginal model of generalized estimating equations was used to adjust for confounding factors and interocular correlation. Results The study included 44 eyes with resolved AAC (mean duration of elevated intraocular pressure, 8.1 ± 10.9 days), 69 eyes with POAG, and 49 control eyes. PCD showed a similar decrease between AAC and POAG eyes (P > 0.99). After adjusting for age and sex, the mean difference in global PCD between each of the POAG stage groups and the AAC group was the highest in the severe POAG group (-3.43; 95% confidence interval [CI], -11.38 to 2.52; P = 0.211), followed by the mild POAG (0.68; 95% CI, -3.26 to 4.62; P = 0.735) and moderate POAG (0.20; 95% CI, -5.21 to 5.61; P = 0.942) groups. The duration of increased intraocular pressure did not affect PCD (P = 0.258 and 0.168 for global and annular PCDs, respectively). Conclusions The degree of microvascular attenuation in AAC eyes was not different from that in POAG eyes. |
| Databáze: | OpenAIRE |
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