Impact of Thrombophilia on the Risk of Hypoxic–Ischemic Encephalopathy in Term Neonates
| Autor: | Hanan G. Abdel-Azeem, Eman M. Monazea, Nafisa H. R. Abdelaziz, Tahra Sherif |
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| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
medicine.medical_specialty Encephalopathy 030204 cardiovascular system & hematology Thrombophilia Hypoxic Ischemic Encephalopathy Pathogenesis Consanguinity 03 medical and health sciences 0302 clinical medicine Risk Factors Humans Point Mutation Medicine Cesarean Section business.industry Incidence (epidemiology) Infant Newborn Factor V Blood Proteins Hematology General Medicine medicine.disease Term neonates Neonatal Hypoxic Ischemic Encephalopathy Case-Control Studies Hypoxia-Ischemia Brain Prothrombin business Limited resources 030217 neurology & neurosurgery |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis. 23:266-273 |
| ISSN: | 1938-2723 1076-0296 |
| DOI: | 10.1177/1076029615607302 |
| Popis: | Background: The incidence of neonatal hypoxic–ischemic encephalopathy (HIE) is reportedly high in countries with limited resources. Its pathogenesis is multifactorial. A role for thrombophilia has been described in different patterns of preterm and full-term perinatal brain injury. Aim: This study aims to identify risk factors associated with neonatal HIE and also to determine the contributions of genetic thrombophilia in the development of neonatal HIE. Methods: Sixty-seven neonates with HIE and 67 controls were enrolled in the study. Clinical history and examination were undertaken. Patients and controls were tested for the presence of factor V G1691A and prothrombin G20210A mutations. In addition, protein S, protein C, and antithrombin III levels were assessed. Results: Parental consanguinity and performing emergency cesarean section (CS) were significant risk factors for neonatal HIE (odds ratio [OR] 6.5, 95% confidence interval [CI] 2.6-15.3, P < .001, OR 12.6, 95% CI 2.52-63.3, P = .002, respectively). No significant difference was found regarding maternal age and parity. About 33% of cases and 6% of controls were found to have at least 1 thrombophilic factor ( P < .001). Factor V G1691A mutation significantly increased the risk of neonatal HIE (OR 4.5, 95% CI 1.4-14.5, P = .012), while prothrombin G 20210A mutation and protein C deficiency were not. Conclusion: Parental consanguinity, emergency CS, and factor V mutation may contribute to the higher risk of developing neonatal HIE. |
| Databáze: | OpenAIRE |
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