Nutritional Supplementation Inhibits the Increase in Serum Malondialdehyde in Patients with Wet Age-Related Macular Degeneration

Autor: Taichi Tsunekawa, Kei Takayama, Shiang-Jyi Hwang, Fuxiang Ye, Hiroshi Fukukita, Keiko Kataoka, Yasuki Ito, Hiroki Kaneko, Yosuke Nagasaka, Toshiyuki Matsuura, Hiroko Terasaki
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Aging
medicine.medical_specialty
Nutritional Supplementation
Article Subject
genetic structures
medicine.disease_cause
Biochemistry
Gastroenterology
Lesion
03 medical and health sciences
chemistry.chemical_compound
Macular Degeneration
0302 clinical medicine
Internal medicine
Malondialdehyde
Wet age-related macular degeneration
medicine
Humans
In patient
lcsh:QH573-671
skin and connective tissue diseases
Aged
business.industry
lcsh:Cytology
Cell Biology
General Medicine
Macular degeneration
medicine.disease
eye diseases
Choroidal Neovascularization
030104 developmental biology
Choroidal neovascularization
chemistry
Immunology
Dietary Supplements
030221 ophthalmology & optometry
Wet Macular Degeneration
Female
sense organs
medicine.symptom
business
Oxidative stress
Research Article
Zdroj: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
ISSN: 1942-0994
1942-0900
Popis: Purpose. To compare serum levels of malondialdehyde (MDA) in patients with wet age-related macular degeneration (wAMD), patients with dry AMD (dAMD), and patients without AMD and to evaluate the efficacy of nutritional supplementation for treating elevated serum MDA in patients with wAMD. Methods. MDA levels were measured in sera from 20 patients with wAMD, 20 with dAMD, and 24 without AMD. Patients with wAMD were randomized to receive or not receive nutritional supplementation (10 patients in each group), and MDA levels were measured after 3 months of treatment. Results. MDA levels in patients with wAMD were significantly greater compared with patients without AMD. In eyes with wAMD, there was a significant correlation between MDA levels and choroidal neovascularization lesion area. Serum MDA levels decreased in most patients that received supplementation and significantly increased in those who did not. Conclusion. Baseline serum MDA levels were elevated in patients with wAMD, and MDA levels were directly correlated with choroidal neovascularization lesion area. In addition, nutritional supplementation appeared to exert a protective effect against oxidative stress in patients with wAMD.
Databáze: OpenAIRE
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