Quantitative and clinical impact of MRI-based attenuation correction methods in[18F]FDG evaluation of dementia
| Autor: | Erik Magnus Berntsen, Thomas Schwarzlmüller, Anna Karlberg, Live Eikenes, Joel Fredrik Aanerud, Silje Kjærnes Øen, Thomas Morten Keil, Claes Nøhr Ladefoged |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Attenuation correction medicine.diagnostic_test business.industry lcsh:R895-920 z-scores dementia Magnetic resonance imaging medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine PET/MRI Positron emission tomography Medical imaging medicine Dementia Diagnostic assessment Radiology Nuclear Medicine and imaging Medical diagnosis business Nuclear medicine Correction for attenuation 030217 neurology & neurosurgery Cardiac imaging |
| Zdroj: | EJNMMI Research Øen, S K, Keil, T M, Berntsen, E M, Aanerud, J F, Schwarzlmüller, T, Ladefoged, C N, Karlberg, A M & Eikenes, L 2019, ' Quantitative and clinical impact of MRI-based attenuation correction methods in [ 18 F]FDG evaluation of dementia ', EJNMMI research, vol. 9, no. 1, 83, pp. 1-12 . https://doi.org/10.1186/s13550-019-0553-2 EJNMMI Research, Vol 9, Iss 1, Pp 1-12 (2019) |
| DOI: | 10.1186/s13550-019-0553-2 |
| Popis: | Background: Positron emission tomography/magnetic resonance imaging (PET/MRI) is a promising diagnostic imaging tool for the diagnosis of dementia, as PET can add complementary information to the routine imaging examination with MRI. The purpose of this study was to evaluate the influence of MRI-based attenuation correction (MRAC) on diagnostic assessment of dementia with [18F]FDG PET. Quantitative differences in both [18F]FDG uptake and z-scores were calculated for three clinically available (DixonNoBone, DixonBone, UTE) and two research MRAC methods (UCL, DeepUTE) compared to CT-based AC (CTAC). Furthermore, diagnoses based on visual evaluations were made by three nuclear medicine physicians and one neuroradiologist (PETCT, PETDeepUTE, PETDixonBone, PETUTE, PETCT + MRI, PETDixonBone + MRI). In addition, pons and cerebellum were compared as reference regions for normalization. Results: The mean absolute difference in z-scores were smallest between MRAC and CTAC with cerebellum as reference region: 0.15 ± 0.11 σ (DeepUTE), 0.15 ± 0.12 σ (UCL), 0.23 ± 0.20 σ (DixonBone), 0.32 ± 0.28 σ (DixonNoBone), and 0.54 ± 0.40 σ (UTE). In the visual evaluation, the diagnoses agreed with PETCT in 74% (PETDeepUTE), 67% (PETDixonBone), and 70% (PETUTE) of the patients, while PETCT + MRI agreed with PETDixonBone + MRI in 89% of the patients. Conclusion: The MRAC research methods performed close to that of CTAC in the quantitative evaluation of [18F]FDG uptake and z-scores. Among the clinically implemented MRAC methods, DixonBone should be preferred for diagnostic assessment of dementia with [18F]FDG PET/MRI. However, as artifacts occur in DixonBone attenuation maps, they must be visually inspected to assure proper quantification. |
| Databáze: | OpenAIRE |
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