SHP2 and UGP2 are Biomarkers for Progression and Poor Prognosis of Gallbladder Cancer
| Autor: | Guixiang Zeng, Yuan Yuan, Qunwei Wang, Zhulin Yang, Qiong Zou, Lufeng Liang, Senlin Chen, Jinghe Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty MMP2 UTP-Glucose-1-Phosphate Uridylyltransferase Adenosquamous carcinoma Protein Tyrosine Phosphatase Non-Receptor Type 11 Vimentin Kaplan-Meier Estimate Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Neoplasm Metastasis Gallbladder cancer Stage (cooking) Aged Neoplasm Staging Aged 80 and over biology business.industry Gallbladder General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Tumor Burden 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Disease Progression biology.protein Adenocarcinoma Female Gallbladder Neoplasms Neoplasm Grading business |
| Zdroj: | Cancer Investigation. 34:255-264 |
| ISSN: | 1532-4192 0735-7907 |
| DOI: | 10.1080/07357907.2016.1193745 |
| Popis: | Biomarkers for the diagnosis, prognosis, and targeting therapy of gallbladder cancers are not clinically available. This study demonstrated that the percentage of cases with positive SHP2 and UGP2 expression significantly correlated with the percentage of cases with positive vimentin, β-catenin, MMP2, MMP9, and Ki-67 expression, large tumor size, high TNM stage, lymph node metastasis, and survival in patients with adenocarcinomas and squamous cell/adenosquamous carcinomas. Positive SHP2 and UGP2 expression are independent poor-prognostic factors in both types of tumors. Our study suggested that positive SHP2 and UGP2 expression correlated with clinicopathological and biological behaviors, and poor-prognosis of gallbladder cancer. |
| Databáze: | OpenAIRE |
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