Parkin, an E3 Ubiquitin Ligase, Plays an Essential Role in Mitochondrial Quality Control in Parkinson’s Disease
| Autor: | Nai-Hong Chen, Yi Zhang, Yu-He Yuan, Xiao-Le Wang, Zhen-Zhen Wang, Si-Tong Feng |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Mitochondrial DNA Parkinson's disease Ubiquitin-Protein Ligases PINK1 Biology Parkin 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Parkinsonian Disorders Mitophagy medicine Animals Humans Parkinson Disease Cell Biology General Medicine medicine.disease LRRK2 Mitochondria nervous system diseases Ubiquitin ligase Cell biology 030104 developmental biology Mitochondrial biogenesis Mutation biology.protein 030217 neurology & neurosurgery |
| Zdroj: | Cellular and Molecular Neurobiology. 41:1395-1411 |
| ISSN: | 1573-6830 0272-4340 |
| DOI: | 10.1007/s10571-020-00914-2 |
| Popis: | Parkinson's disease (PD), as one of the complex neurodegenerative disorders, affects millions of aged people. Although the precise pathogenesis remains mostly unknown, a significant number of studies have demonstrated that mitochondrial dysfunction acts as a major role in the pathogeny of PD. Both nuclear and mitochondrial DNA mutations can damage mitochondrial integrity. Especially, mutations in several genes that PD-linked have a closed association with mitochondrial dysfunction (e.g., Parkin, PINK1, DJ-1, alpha-synuclein, and LRRK2). Parkin, whose mutation causes autosomal-recessive juvenile parkinsonism, plays an essential role in mitochondrial quality control of mitochondrial biogenesis, mitochondrial dynamics, and mitophagy. Therefore, we summarized the advanced studies of Parkin's role in mitochondrial quality control and hoped it could be studied further as a therapeutic target for PD. |
| Databáze: | OpenAIRE |
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