Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure
| Autor: | Philippe Amouyel, Nicolas Lamblin, Claude Foucher-Hossein, Pascal de Groote, Xavier Hermant, Jean Dallongeville, Eugène P. Mc Fadden, Nicole Helbecque, Christophe Bauters |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Maximum Tolerated Dose Heart disease Adrenergic beta-Antagonists Carbazoles Down-Regulation Ventricular Function Left Propanolamines Beta-1 adrenergic receptor Radionuclide angiography Gene Frequency Internal medicine Heart rate Genetics medicine Bisoprolol Humans Prospective Studies cardiovascular diseases General Pharmacology Toxicology and Pharmaceutics Codon Molecular Biology Carvedilol Alleles Genetics (clinical) Aged Heart Failure Polymorphism Genetic Ejection fraction medicine.diagnostic_test business.industry Angiography Middle Aged medicine.disease Treatment Outcome Endocrinology Echocardiography Heart failure cardiovascular system Cardiology Molecular Medicine Female Receptors Adrenergic beta-1 business Pharmacogenetics medicine.drug |
| Zdroj: | Pharmacogenetics and Genomics. 15:137-142 |
| ISSN: | 1744-6872 |
| Popis: | Previous studies have clearly demonstrated the beneficial effect of beta-blockers in patients with stable congestive heart failure (CHF). beta-blockers improve left ventricular ejection fraction (LVEF) and reduce cardiac mortality. However, there is an interindividual variability in the response to these agents. Two studies have suggested a possible impact of some functional betaAR gene polymorphisms on the effects of beta-blockade. The objective of the study is to analyse the association between genetic variations in the beta1 or the beta2 adrenoreceptor (AR) gene and the effects of beta-blockade in patients with stable CHF. We studied 199 consecutive patients with stable CHF not treated with beta-blockers. Before introduction of beta-blockers and 3 months after the maximal tolerated dose was reached, patients underwent an echocardiography and a radionuclide angiography. The beta1ARGly389Arg, beta1ARSer49Gly, beta2ARGly16Arg, beta2ARGln27Glu and beta2ARThr164Ile polymorphisms were determined: beta-blockade resulted in a significant decrease in heart rate, a significant increase in LVEF (from 30+/-10% to 40+/-13%, P |
| Databáze: | OpenAIRE |
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