Exploring new roles for actin upon LTP induction in dendritic spines
| Autor: | Mayte Bonilla-Quintana, Florentin Woergoetter |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
Dendritic spine Dendritic Spines Science Long-Term Potentiation Cell macromolecular substances Article Synaptic plasticity Exocytosis Computational biophysics 03 medical and health sciences 0302 clinical medicine medicine LTP induction Animals Actin 030304 developmental biology 0303 health sciences Chemistry Neurosciences Lipid bilayer fusion musculoskeletal system Actins Spine (zoology) medicine.anatomical_structure Membrane Biophysics Medicine Biophysical models 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports Scientific reports, vol 11, iss 1 |
| DOI: | 10.1101/2020.11.14.382663 |
| Popis: | Dendritic spines, small protrusions of the dendrites, enlarge upon LTP induction, linking morphological and functional properties. Although the role of actin in spine enlargement has been well studied, little is known about its relationship with mechanical membrane properties, such as membrane tension, which is involved in many cell processes, like exocytosis. Here, we use a 3D model of the dendritic spine to investigate how polymerization of actin filaments can effectively elevate the membrane tension to trigger exocytosis in a domain close to the tip of the spine. Moreover, we show that the same pool of actin promotes full membrane fusion after exocytosis and spine stabilization. |
| Databáze: | OpenAIRE |
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