Injectable and Self‐Healing Hydrogel with Anti‐Bacterial and Anti‐Inflammatory Properties for Acute Bacterial Rhinosinusitis with Micro Invasive Treatment
| Autor: | Tao Zhang, Minhui Zhu, Chengjing Zhu, Zhengwei Cai, Haihong Tang, Xianmin Song, Yanghua Qin, Wenguo Cui, Hongliang Zheng, Zhengming Chen |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.drug_class media_common.quotation_subject Anti-Inflammatory Agents Biomedical Engineering Pharmaceutical Science Biocompatible Materials macromolecular substances 02 engineering and technology Drug resistance Polyethylene Glycol Hydrogel Pharmacology 010402 general chemistry 01 natural sciences Anti-inflammatory Polyethylene Glycols Biomaterials In vivo Clarithromycin Animals Medicine Adverse effect media_common business.industry technology industry and agriculture Hydrogels 021001 nanoscience & nanotechnology 0104 chemical sciences Drug Liberation Self-healing hydrogels Rabbits 0210 nano-technology business medicine.drug |
| Zdroj: | Advanced Healthcare Materials. 9:2001032 |
| ISSN: | 2192-2659 2192-2640 |
| Popis: | Systemic antibiotic therapy is the main treatment for acute bacterial rhinosinusitis (ABRS). However, this treatment often causes side effects of dizziness, diarrhea, and drug resistance. In this study, a new polyethylene glycol hydrogel (PEG-H) treatment model is developed to achieve sustained release of drugs at the locality while avoiding those adverse effects. The PEG-H is composed of 4-arm-PEG-SH and silver ions through a high affinity and dynamic reversible coordination bond between the thiol and silver ion. In the initial test, PEG-H is loaded with Clarithromycin (CAM-Lips@Hydrogel) or Clarithromycin and Budesonide liposomes (CAM+BUD-Lips@Hydrogel). The results show that PEG-H maintains the characteristics of self-healing, biodegradability, moderate swelling rate, injectibility and sustained drug release. In in vivo studies, the hydrogel is injected into the maxillary sinus of ABRS rabbit models. In both a single or combined load, the hydrogel not only plays an effective role as an anti-bacterial, but also inhibits inflammatory response of local sinus mucosa. In addition, no other side effects are observed in the ABRS rabbit model through behavioral observation and drug sensitivity tests. Therefore, the injectable self-healing hydrogel with anti-bacterial and anti-inflammatory properties provides a new micro invasive therapeutic method for the clinical treatment of ABRS. |
| Databáze: | OpenAIRE |
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