Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children
Autor: | Matthew C. Strehlow, Dean S. Carson, Samuel H. Cheshier, Shellie A. Hyde, Joseph P. Garner, T H Trujillo, J K Moss, Antonio Y. Hardan, Karen J. Parker, Sonia Partap, Lisa Jackson, Sean Berquist, S L Hannah, Raena D. Sumiyoshi |
---|---|
Rok vydání: | 2014 |
Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent Statistics as Topic Anxiety Neuropsychological Tests Oxytocin Young Adult Cellular and Molecular Neuroscience Cerebrospinal fluid Predictive Value of Tests Internal medicine mental disorders medicine Humans Young adult Child Molecular Biology Extramural Middle Aged Psychiatry and Mental health Endocrinology Child Preschool Predictive value of tests Female medicine.symptom Psychology Biomarkers psychological phenomena and processes hormones hormone substitutes and hormone antagonists Clinical psychology medicine.drug |
Zdroj: | Molecular Psychiatry. 20:1085-1090 |
ISSN: | 1476-5578 1359-4184 |
Popis: | The neuropeptide oxytocin (OXT) exerts anxiolytic and prosocial effects in the central nervous system of rodents. A number of recent studies have attempted to translate these findings by investigating the relationships between peripheral (e.g., blood, urinary and salivary) OXT concentrations and behavioral functioning in humans. Although peripheral samples are easy to obtain in humans, whether peripheral OXT measures are functionally related to central OXT activity remains unclear. To investigate a possible relationship, we quantified OXT concentrations in concomitantly collected cerebrospinal fluid (CSF) and blood samples from child and adult patients undergoing clinically indicated lumbar punctures or other CSF-related procedures. Anxiety scores were obtained in a subset of child participants whose parents completed psychometric assessments. Findings from this study indicate that plasma OXT concentrations significantly and positively predict CSF OXT concentrations (r=0.56, P=0.0064, N=27). Moreover, both plasma (r=-0.92, P=0.0262, N=10) and CSF (r=-0.91, P=0.0335, N=10) OXT concentrations significantly and negatively predicted trait anxiety scores, consistent with the preclinical literature. Importantly, plasma OXT concentrations significantly and positively (r=0.96, P=0.0115, N=10) predicted CSF OXT concentrations in the subset of child participants who provided behavioral data. This study provides the first empirical support for the use of blood measures of OXT as a surrogate for central OXT activity, validated in the context of behavioral functioning. These preliminary findings also suggest that impaired OXT signaling may be a biomarker of anxiety in humans, and a potential target for therapeutic development in individuals with anxiety disorders. |
Databáze: | OpenAIRE |
Externí odkaz: |